Reaktion #7341

Reaktionsgleichung

6b

4-Bromo-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol

2-tributylstannylthiazole

→

2-(3-Fluoro-4-hydroxyphenyl)-4-thiazol-2-yl-quinolin-6-ol

Ausbeute 56.0%

Reaktionsbedingungen

Vorschrift

This compound was prepared from 6b and 2-tributylstannylthiazole according to method J. Yellow powder; Yield: 56%; mp>280° C. (dec.); 1H-NMR (400 MHz, DMSO-d6) δ 7.10 (t, J=8.8 Hz, 1H), 7.38 (dd, J=9.1, 2.7 Hz, 1H), 7.95–8.00 (m, 2H), 8.07–8.12 (m, 3H), 8.21 (m, 2H), 10.18 (s, 1H), 10.26 (s, 1H); MS (ESI) m/z 337 ([M−H]−), 339 ([M+H]+); Anal. Calcd for C18H11FN2O2S: C: 63.90, H: 3.28, N: 8.28. Found: C: 62.6, H: 3.43, N: 7.59.

Quelle