Reaktion #7340

Reaktionsgleichung

6b

4-Bromo-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol

tributyl(phenylethynyl)tin

→

2-(3-Fluoro-4-hydroxyphenyl)-4-(phenylethynyl)quinolin-6-ol

Ausbeute 92.0%

Reaktionsbedingungen

Vorschrift

This compound was prepared from 6b and tributyl(phenylethynyl)tin according to method J. Orange powder; Yield: 92%; mp 125–129° C; 1H-NMR (300 MHz, DMSO-d6) δ 7.08 (dd, J=8.8, 8.8 Hz, 1H), 7.36 (dd, J=9.0, 2.6 Hz, 1H), 7.53 (m, 3H), 7.59 (d, J=2.6 Hz, 1H), 7.74 (m, 2H), 7.94 (d, J=9.1 Hz, 2H), 8.05 (dd, J=13.0, 1.8 Hz, 1H), 8.18 (s, 1H), 10.23 (s, 1H), 10.26 (s, 1H); 19F-NMR (300 MHz, DMSO-d6) δ −136.48 (dd, J=13.7, 9.2 Hz); MS (ESI) m/z 354 ([M−H]−), 356 ([M+H]+); Anal. Calcd for C23H14FNO2: C: 77.74, H: 3.97, N: 3.94. Found: C: 76.45, H: 3.88, N: 3.77.

Quelle