Reaktion #73358

Reaktionsgleichung

4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester

potassium tert-butoxide

→

(±)-1-Benzyl-2-methyl-3-oxo-piperidine-4-carboxylic acid methyl ester

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture is then partitioned between DCM and saturated aqueous NH4Cl
2. 2
   SonstigeThe organic layer is removed
3. 3
   Trocknendried over anhydrous Na2SO4
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe crude residue is used without further purification

Vorschrift

A mixture of 4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester (1.5 g, 4.9 mmol), potassium tert-butoxide (906 mg, 8.9 mmol) and toluene (100 mL) is stirred at rt for 3 h. The mixture is then partitioned between DCM and saturated aqueous NH4Cl. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated. The crude residue is used without further purification.

Quelle