Reaktion #73334

Reaktionsgleichung

potassium carbonate

benzyl alcohol

1,2-difluoro-3-methyl-4-nitrobenzene

→

1-benzyloxy-2-fluoro-3-methyl-4-nitrobenzene

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   EinengenThe organic layer is concentrated
3. 3
   Sonstigethe residue is separated with FCC (EtOAc/heptane from 0 to 20%)

Vorschrift

To a suspension of potassium carbonate (19.2 g, 138 mmol) and benzyl alcohol (22 mL) is added 1,2-difluoro-3-methyl-4-nitrobenzene (12 g, 69 mmol, ref. WO2007121416) and the mixture is heated to 180° C. for 2 h. The reaction mixture is then diluted with EtOAc and washed with water. The organic layer is concentrated and the residue is separated with FCC (EtOAc/heptane from 0 to 20%) to give 1-benzyloxy-2-fluoro-3-methyl-4-nitrobenzene. 1H NMR (400 MHz, MeOD) δ ppm 7.87 (dd, J=9.35, 2.02 Hz, 1 H), 7.44-7.47 (m, 2 H), 7.32-7.41 (m, 3 H), 7.17 (t, J=8.72 Hz, 1 H), 5.26 (s, 2 H), 2.49 (d, J=2.78 Hz, 3 H).

Quelle