Reaktion #73295

Reaktionsgleichung

1,4-Dioxaspiro[4.5]decan-8-ol

methanesulfonyl chloride

→

1,4-Dioxaspiro[4.5]dec-8-yl methanesulfonate

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe reaction was extracted with ethyl acetate
2. 2
   Waschenthe organic extracts were washed with water, and saturated NaCl
3. 3
   Trocknendried (MgSO4)
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe crude product was used in the next reaction without further purification

Vorschrift

1,4-Dioxaspiro[4.5]decan-8-ol (0.40 g, 0.0025 mol) was dissolved in chloroform (10.0 mL) and the resulting mixture was cooled at 0° C. To the mixture was added TEA (0.49 mL, 0.0035 mol) and methanesulfonyl chloride (0.23 mL, 0.0030 mol) and this mixture was stirred at 0° C. for 2 hours. The reaction was extracted with ethyl acetate and the organic extracts were washed with water, and saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification.

Quelle