Reaktion #732520

Reaktionsgleichung

compound ( G )

Cyclobutyl-(4-methoxy-phenyl)-methanone

hydrazine hydrate

K2CO3

→

oil

Ausbeute 95.0%

1-Cyclobutylmethyl-4-methoxy-benzene

Ausbeute 95.0%

Lösungsmittel

diethylene glycol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwere heated
2. 2
   Temperaturto reflux temperature for 1 hour
3. 3
   workup.DISTILLATIONthe mixture was distilled at 220-230° C
4. 4
   ExtraktionThe distillate was extracted with MTBE
5. 5
   Waschenthe organic phase washed with water and brine
6. 6
   Trocknendried (MgSO4)
7. 7
   Einengenconcentrated in vacuo
8. 8
   SonstigeThe residue was purified by chromatography

Vorschrift

A mixture of compound (G) (5.00 g), hydrazine hydrate (4.12 g), K2CO3 (7.00 g) and diethylene glycol (16 ml) were heated to reflux temperature for 1 hour. The condenser was exchanged by a distillation device and the mixture was distilled at 220-230° C. The distillate was extracted with MTBE and the organic phase washed with water and brine, dried (MgSO4) and concentrated in vacuo. The residue was purified by chromatography to yield a colorless oil (4.4 g).

Quelle