Reaktion #73186

Reaktionsgleichung

4-(4-bromo-3-methyl-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine

(3-cyanophenyl)boronic acid

sodium carbonate

1,2-dimethoxyethane

water

→

product

Ausbeute 44.0%

3-[3-Methyl-1-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-4-yl]benzonitrile

Ausbeute 44.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeresulted
2. 2
   TemperaturThe reaction mixture then was cooled to room temperature (rt)
3. 3
   Filtrationfiltered
4. 4
   Waschenwas washed with water (×2) and dimethyl ether (DME) (×2)

Vorschrift

A mixture of 4-(4-bromo-3-methyl-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine (0.032 g, 0.00012 mol), (3-cyanophenyl)boronic acid (0.027 g, 0.00018 mol), sodium carbonate (0.032 g, 0.00030 mol) and tetrakis(triphenylphosphine)palladium(0) (7.0 mg, 0.0000060 mol) in 1,2-dimethoxyethane (0.3 mL, 0.003 mol) and water (0.3 mL, 0.02 mol) was heated at 130° C. (a liquid resulted, but with two layers) for 4 h. The reaction mixture then was cooled to room temperature (rt), filtered and was washed with water (×2) and dimethyl ether (DME) (×2) to give the product as a pale orange solid (15 mg, 44% yield).

Quelle