Reaktion #73152

ord-39df888f8fc948f597dbf2fb25b2dc4e

Reaktionsgleichung

CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CC1
Intermediate O
CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CC1
(R)-2-chloro-8-cyclopropyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one
c1ncc(-c2ncc[nH]2)cn1
5-(1H-imidazol-2-yl)pyrimidine
→
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3-c3cncnc3)nc2N1C1CC1
title compound
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3-c3cncnc3)nc2N1C1CC1
(R)-8-cyclopropyl-7-ethyl-5-methyl-2-(2-(pyrimidin-5-yl)-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one

Edukte

CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CC1
Intermediate O
CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C1CC1
(R)-2-chloro-8-cyclopropyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one
c1ncc(-c2ncc[nH]2)cn1
5-(1H-imidazol-2-yl)pyrimidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared similarly to the methods described in Example 77, with Intermediate O instead of Intermediate C and with 5-(1H-imidazol-2-yl)pyrimidine instead of 2-phenyl-1H-imidazole. LCMS: 377.1 m/z (M+H)+; ret. Time: 4.44 min (Analytical Method C).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541418B2uspto-grants-2013_09