Reaktion #731366

Reaktionsgleichung

2-[4-(tert-Butyl)-2-(1-Boc-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)-4-chlorobenzamide

→

white solid

Ausbeute 46.7%

2-[4-(tert-Butyl)-2-(piperidin-4-yloxy)benzoylamino]-4-chloro-N-(5-chloro-pyridin-2-yl)benzamide hydrochloride

Ausbeute 46.7%

Lösungsmittel

HCl p-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe solution was concentrated in vacuo
2. 2
   Sonstigethe residue was purified by RPHPLC
3. 3
   Wascheneluting with a gradient of 20% through 60% acetonitrile in 0.05% aq HCl over 320 min
4. 4
   workup.ADDITIONThe clean product containing fractions
5. 5
   Einengenpartially concentrated

Vorschrift

2-[4-(tert-Butyl)-2-(1-Boc-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)-4-chlorobenzamide (0.4 g, 0.64 mmol) was dissolved in 4 N HCl/p-dioxane (15 mL). After stirring for 30 min, the solution was concentrated in vacuo and the residue was purified by RPHPLC, eluting with a gradient of 20% through 60% acetonitrile in 0.05% aq HCl over 320 min. The clean product containing fractions were combined, partially concentrated and lypholyzed to give 0.0864 g (23%) of white solid.

Quelle