Reaktion #7312

Reaktionsgleichung

5-chlorobenzotriazole

chloroacetone

potassium carbonate

potassium iodide

→

1-(5-chlorobenzotriazol-1-yl)-propan-2-one

1-(6-chlorobenzotriazol-1-yl)-propan-2-one

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture is subsequently filtered
2. 2
   Einengenthe filtrate concentrated by evaporation in a vacuum
3. 3
   Sonstigethe residue purified by flash chromatography

Vorschrift

A mixture of 5 g of 5-chlorobenzotriazole, 1.4 g of chloroacetone, 5.1 g of potassium carbonate and 0.5 g of potassium iodide is stirred into 50 ml of acetone at room temperature for 48 h. The mixture is subsequently filtered, the filtrate concentrated by evaporation in a vacuum, and the residue purified by flash chromatography. In this way, two isomeric products, 1-(5-chlorobenzotriazol-1-yl)-propan-2-one and 1-(6-chlorobenzotriazol-1-yl)-propan-2-one, are isolated in approximately the same quantities, the first of which is then used directly in the next step.

Quelle