Reaktion #73118

ord-2f04e6b51f8948e3a05e02bc18dd711d

Reaktionsgleichung

CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)O)n3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-3-carboxylic acid
CC(=O)[O-].[NH4+]
ammonium acetate
→
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(N)=O)n3)nc2N1C1CCCC1
title compound
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(N)=O)n3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-3-carboxamide

Edukte

CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)O)n3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-3-carboxylic acid
CC(=O)[O-].[NH4+]
ammonium acetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared similarly to the methods described in Example 39, with (R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-3-carboxylic acid (Example 56) used instead of (R)-1-(8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-4-carboxylic acid (Example 44) and ammonium acetate instead of dimethylamine hydrochloride. LCMS: 370.1 m/z (M+H)+; ret. Time: 3.39 min (Analytical Method A).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541418B2uspto-grants-2013_09