Reaktion #73116

ord-31fa93e1a27743d0b0d5d1c4da497f14

Reaktionsgleichung

CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)O)n3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-3-carboxylic acid
CN.Cl
methylamine hydrochloride
→
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)NC)n3)nc2N1C1CCCC1
title compound
CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)NC)n3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-N-methyl-1H-pyrazole-3-carboxamide

Edukte

CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)O)n3)nc2N1C1CCCC1
(R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-3-carboxylic acid
CN.Cl
methylamine hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared similarly to the methods described in Example 39, with (R)-1-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-3-carboxylic acid (Example 56) used instead of (R)-1-(8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)-1H-pyrazole-4-carboxylic acid (Example 44) and methylamine hydrochloride instead of dimethylamine hydrochloride. LCMS: 384.2 m/z (M+H)+; ret. Time: 3.65 min (Analytical Method A).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541418B2uspto-grants-2013_09