Reaktion #73098

Reaktionsgleichung

isoquinoline 2-oxide

diethyl phosphoro-cyanidate

→

isoquinoline-1-carbonitrile

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed for 18 h
2. 2
   Extraktionextracted with DCM
3. 3
   EinengenThe organic layer was concentrated
4. 4
   Sonstigepurified by silica column chromatography

Vorschrift

To a stirred solution of isoquinoline 2-oxide (2-Im-9, 5.8 g) in 140 mL of acetonitrile, diethyl phosphoro-cyanidate (1.5 eq) was added under argon followed by slow addition of TEA (3.0 eq). The mixture was refluxed for 18 h and then extracted with DCM. The organic layer was concentrated and purified by silica column chromatography to give isoquinoline-1-carbonitrile (3-Im-9).

Quelle