Reaktion #73088

ord-a7bce6362165468fa455f7ec24641f1b

Reaktionsgleichung

O=C1CC[C@H](C(=O)O)N1
D-pyroglutamic acid
CCO
EtOH
→
CCOC(=O)[C@H]1CCC(=O)N1
(R)-ethyl 5-oxopyrrolidine-2-carboxylate

Edukte

O=C1CC[C@H](C(=O)O)N1
D-pyroglutamic acid
CCO
EtOH

Reagenzien

Keine

Lösungsmittel

O=S(=O)(O)O
sulfuric acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturThe mixture was heated
  2. 2
    Temperaturunder reflux overnight
  3. 3
    SonstigeSolvent was removed under reduced pressure

Vorschrift

To a solution of D-pyroglutamic acid (compound I-A, 20.4 g, 0.16 mol) in 100 mL of EtOH, 1.2 mL of conc. sulfuric acid was added. The mixture was heated under reflux overnight. Solvent was removed under reduced pressure to give (R)-ethyl 5-oxopyrrolidine-2-carboxylate (compound II-AA).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541418B2uspto-grants-2013_09