Reaktion #73086

Reaktionsgleichung

(R)-pyrrolidine-2-carboxylic acid

methylpyrrolidine-2-carboxylate

2,4-dichloro-5-nitropyrimidine

compound II

(R)-methyl 2-aminobutanoate

(R)-2-aminobutanoic acid

→

Intermediate E

(R)-2-Chloro-5-methyl-6a,7,8,9-tetrahydropyrrolo[2,1-h]pteridin-6(5H)-one

Reaktionsbedingungen

Vorschrift

Intermediate E was prepared in the same manner as intermediate B, using (R)-pyrrolidine-2-carboxylic acid as the starting material instead of (R)-2-aminobutanoic acid. No reductive amination step, such as that used for the conversion of compound II to compound III, was required. Rather, methylpyrrolidine-2-carboxylate was reacted directly with 2,4-dichloro-5-nitropyrimidine in the same manner as is described for the conversion of compound III to intermediate A. 1H NMR (CDCl3) δ: 7.65 (s, 1H), 4.19 (m, 1H), 3.81 (m, 1H), 3.68 (m, 1H), 3.32 (s, 3H), 2.51 (m, 1H), 2.08 (m, 3H).

Quelle