Reaktion #73085

Reaktionsgleichung

(R)-piperidine-2-carboxylic acid

methylpiperidine-2-carboxylate

2,4-dichloro-5-nitropyrimidine

compound II

(R)-methyl 2-aminobutanoate

(R)-2-aminobutanoic acid

→

Intermediate D

(R)-2-Chloro-5-methyl-7,8,9,10-tetrahydro-5H-pyrido[2,1-h]pteridin-6(6aH)-one

Reaktionsbedingungen

Vorschrift

Intermediate D was prepared in the same manner as intermediate B, using (R)-piperidine-2-carboxylic acid as the starting material instead of (R)-2-aminobutanoic acid. No reductive amination step, such as that used for the conversion of compound II to compound III, was required. Rather, methylpiperidine-2-carboxylate was reacted directly with 2,4-dichloro-5-nitropyrimidine in the same manner as is described for the conversion of compound III to intermediate A. 1H NMR (CDCl3) δ: 7.6 (s, 1H), 4.8 (m, 1H), 4.0 (m, 1H), 3.2 (s, 3H), 2.6 (m, 1H), 2.3 (m, 1H), 1.6 (m, 1H), 1.5 (m, 4H).

Quelle