Reaktion #73067

Reaktionsgleichung

1-methyl-4-nitromethylpiperidin-4-ol

→

4-aminomethyl-1-methylpiperidin-4-ol

Ausbeute 106.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor 55 hours
2. 2
   FiltrationThe reaction mixture was filtered through a layer of CELITE
3. 3
   Filtrationfilter aid
4. 4
   Waschenthe filter cake was rinsed with methanol (100 mL)
5. 5
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

Palladium hydroxide (2.3 g of 20% on carbon) was added to a solution of 1-methyl-4-nitromethylpiperidin-4-ol (11.57 g) in ethanol (120 mL). The mixture was placed under hydrogen pressure (50 psi, 3.4×105 Pa) on a Parr apparatus for 55 hours. The reaction mixture was filtered through a layer of CELITE filter aid and the filter cake was rinsed with methanol (100 mL). The filtrate was concentrated under reduced pressure to provide 10.18 g of 4-aminomethyl-1-methylpiperidin-4-ol as a thick oil.

Quelle