Reaktion #730368

Reaktionsgleichung

N,N diethyl-N-methvlamine

chloromethyl methyl ether

→

desired product

N,N-diethyl-N-methyl-N-methoxymethylammonium Chloride

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated to a gradually elevated temperature
2. 2
   workup.STIRRINGstirred at room temperature for 10 hours
3. 3
   Sonstigethe reaction
4. 4
   FiltrationThe reaction mixture was filtered
5. 5
   Sonstigethe solids obtained
6. 6
   Waschenwere washed with 150 g of toluene and 150 g of acetone
7. 7
   Sonstigedried in a vacuum

Vorschrift

A 30.0 g quantity of N,N diethyl-N-methvlamine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 120 g of toluene, followed by nitrogen replacement. Over a period of 1 hour, 31.2 g of chloromethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd.) was added dropwise to the solution at 5° C. The mixture was stirred at 5° C. for 1 hour, heated to a gradually elevated temperature and stirred at room temperature for 10 hours to complete the reaction. The reaction mixture was filtered, and the solids obtained were washed with 150 g of toluene and 150 g of acetone and then dried in a vacuum, giving 53.7 g of the desired product (white solid).

Quelle