Reaktion #73036

Reaktionsgleichung

Sodium carbonate

alanine ethyl ester hydrochloride

benzyl bromide

acetonitrile

→

ethyl 3-dibenzylaminopropionate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through a layer of CELITE
2. 2
   Filtrationfilter aid
3. 3
   WaschenThe filter cake was rinsed with acetonitrile (100 mL)
4. 4
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

Sodium carbonate (21.1 g, 199 mmol) was added to a suspension of fl-alanine ethyl ester hydrochloride (10.2 g, 66.4 mmol) and benzyl bromide (16.2 mL, 136 mmol) in acetonitrile (265 mL). The reaction mixture was stirred at ambient temperature overnight and then filtered through a layer of CELITE filter aid. The filter cake was rinsed with acetonitrile (100 mL). The filtrate was concentrated under reduced pressure to provide 20.28 g of ethyl 3-dibenzylaminopropionate as a pale yellow oil.

Quelle