Reaktion #7302

Reaktionsgleichung

carbapenem hydrochloride

→

carbapenem hydrochloride trihydrate

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto give 20 kg dispersion
2. 2
   workup.DISSOLUTIONdissolved under ice-
3. 3
   Temperaturcooling
4. 4
   Sonstigeto prepare a charge solution
5. 5
   FiltrationThereafter, the solution was aseptically filtered through a 0.2 μm membrane
6. 6
   Filtrationfilter (MCGL20S03, 0.2 μm, Millipore)
7. 7
   Sonstigeequipped with a jacket)
8. 8
   workup.STIRRINGThen, the crystallization tank was stirred
9. 9
   Sonstigeby bubbling with nitrogen at 0 to 15° C.
10. 10
    workup.ADDITION25 L isopropyl alcohol was aseptically added
11. 11
    SonstigeAfter crystallization, 55 L isopropyl alcohol
12. 12
    workup.ADDITIONwas added aseptically
13. 13
    workup.ADDITIONadded
14. 14
    Filtrationthe precipitated crystals were collected aseptically by filtration
15. 15
    WaschenThe crystals were washed with isopropyl alcohol and acetone
16. 16
    Sonstigedried in a nitrogen stream with regulated humidity (20 to 40 RH %) for 10 hours or more

Vorschrift

Water for injection was added to 2000 g titer equivalent amount of novel non-aseptic carbapenem hydrochloride derivative to give 20 kg dispersion. This dispersion was stirred and dissolved under ice-cooling to prepare a charge solution. Thereafter, the solution was aseptically filtered through a 0.2 μm membrane filter (MCGL20S03, 0.2 μm, Millipore) and fed to a crystallization tank (equipped with a jacket). Then, the crystallization tank was stirred by bubbling with nitrogen at 0 to 15° C., and 25 L isopropyl alcohol was aseptically added thereto. After crystallization, 55 L isopropyl alcohol was added aseptically added thereto over 1 hour or so. After aging for a predetermined time, the precipitated crystals were collected aseptically by filtration. The crystals were washed with isopropyl alcohol and acetone, and dried in a nitrogen stream with regulated humidity (20 to 40 RH %) for 10 hours or more, to give novel aseptic carbapenem hydrochloride trihydrate crystals.

Quelle