Reaktion #730196

Reaktionsgleichung

5-Chloro-N-((1-(4-(3-methoxy-2-oxopyridin-1(2H)-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide

BBr3

→

title compound

5-Chloro-N-((1-(4-(3-hydroxy-2-oxopyridin-1(2H)-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in 1 mL and 5 mL DMSO

Vorschrift

5-Chloro-N-((1-(4-(3-methoxy-2-oxopyridin-1(2H)-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide (306 mg, 0.69 mmol, prepared using a similar procedure as described in Example 4) was stirred in 40 mL DCM as a slurry. BBr3 (200 μL, 2.1 mmol) was added. The mixture was stirred for 2 hrs and concentrated in vacuo. The residue was dissolved in 1 mL and 5 mL DMSO and subjected to prep HPLC to isolate the title compound as a white powder. MS found for C19H14ClN5O3S (M+H)+ 428.1, 430.1 (Cl pattern).

Quelle