Reaktion #72925

Reaktionsgleichung

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

diethylether

→

title compound

Ausbeute 92.0%

N′-(1-acetylpiperidin-4-yl)benzohydrazide

Ausbeute 92.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was then filtered on celite
2. 2
   Sonstigethe filtrate evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was redissolved with dichloromethane
4. 4
   Waschenwashed with aqueous NaHCO3
5. 5
   TrocknenThe solvent was dried over sodium sulfate
6. 6
   Sonstigeremoved under reduced pressure
7. 7
   Sonstigeto give

Vorschrift

30 g (0.12 mol) of N′-(1-acetylpiperidin-4-ylidene)benzohydrazide were dissolved in 500 mL of glacial acetic acid and 1 g of PtO2 were added. The mixture was hydrogenated at 40 psi for 12 hours at room temperature. The catalyst was then filtered on celite and the filtrate evaporated in vacuo. The residue was redissolved with dichloromethane and washed with aqueous NaHCO3. The solvent was dried over sodium sulfate and removed under reduced pressure to give, after trituration with diethylether, 28.6 g (92% yield) of the title compound.

Quelle