Reaktion #72924

Reaktionsgleichung

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

Ausbeute 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

Ausbeute 83.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe resulting solution was refluxed for 6 hours
2. 2
   SonstigeThe solvent was then removed in vacuo
3. 3
   Sonstigethe residue partitioned between dichloromethane and water
4. 4
   TrocknenThe organic layer was dried over sodium sulfate
5. 5
   Sonstigeevaporated to dryness

Vorschrift

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

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