Reaktion #72922

ord-36509e16039c4f43b53665e1858e6db9

Reaktionsgleichung

COC(=O)c1cc([N+](=O)[O-])ccc1F
methyl 2-fluoro-5-nitro-benzoate
CN1CCNCC1
N-methylpiperazine
→
COC(=O)c1cc([N+](=O)[O-])ccc1N1CCN(C)CC1
Methyl 2-(4-methyl-piperazin-1-yl)-5-nitro-benzoate

Edukte

COC(=O)c1cc([N+](=O)[O-])ccc1F
methyl 2-fluoro-5-nitro-benzoate
CN1CCNCC1
N-methylpiperazine

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturto reflux for 5 hours

Vorschrift

A solution of methyl 2-fluoro-5-nitro-benzoate (3.487 g, 17.511 mmol) and N-methylpiperazine (3.855 mL, 3.508 g, 35.022 mmol) in 30 mL of anhydrous methanol was heated to reflux for 5 hours.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541429B2uspto-grants-2013_09