Reaktion #7292

Reaktionsgleichung

1,4-dibromo-2,5-dimethoxy benzene

phenylacetylene

→

desired product

Ausbeute 75.7%

1,4-bis(phenylethynyl)-2,5-dimethoxybenzene

Ausbeute 75.7%

Lösungsmittel

piperidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a stirrer
2. 2
   Temperaturthe reaction mixture was cooled down to room temperature
3. 3
   Filtrationwas filtered off
4. 4
   SonstigeThe solvent was removed under a reduced pressure
5. 5
   Extraktionthe residue was extracted with methylene chloride
6. 6
   WaschenOrganic layer was washed with water several times
7. 7
   Trocknendried with anhydrous magnesium sulfate
8. 8
   Sonstigethe solvent was removed
9. 9
   Sonstigeto obtain yellow solid
10. 10
    SonstigeThis solid was recrystallized from ethyl acetate
11. 11
    Sonstigeto obtain yellow crystal, which
12. 12
    Sonstigewas sufficiently dried in a vacuum oven at 40° C.

Vorschrift

50 g (160 mmol) of 1,4-dibromo-2,5-dimethoxy benzene, 3.6 g (0.005 mol) of bistriphenylphosphine palladium dichloride and 0.97 g (0.005 mol) of copper iodide were put into a 1 litter 3-neck flask equipped with a stirrer, a thermometer and a reflux condenser under an argon atmosphere, and dissolved in 500 ml of piperidine. 43 g (0.422 mol) of phenylacetylene was then slowly added dropwise at room temperature. The reaction temperature was slowly raised to 80° C. and then the reaction mixture was stirred at the same temperature for 12 hours. When the reaction was completed, the reaction mixture was cooled down to room temperature, and then generated salt was filtered off. The solvent was removed under a reduced pressure, and then the residue was extracted with methylene chloride. Organic layer was washed with water several times and dried with anhydrous magnesium sulfate, and then the solvent was removed to obtain yellow solid. This solid was recrystallized from ethyl acetate to obtain yellow crystal, which was sufficiently dried in a vacuum oven at 40° C. to give 41 g (yield: 72%) of the desired product, and its melting point was 172° C.–174° C.

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