Reaktion #7281

Reaktionsgleichung

4-hydroxymethyl-benzaldehyde

2-aminopyridine

acetic acid

sodium triacetoxyborohydride

→

title compound

Ausbeute 74.0%

[4-(Pyridin-2-ylaminomethyl)-phenyl]-methanol

Ausbeute 74.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeone hour at 50° C., followed by purification of crude material

Vorschrift

Using general procedure B: Reaction of 4-hydroxymethyl-benzaldehyde (1.01 g, 7.42 mmol), 2-aminopyridine (697 mg, 7.42 mmol), acetic acid (0.5 mL) and sodium triacetoxyborohydride (3.2 g, 14.8 mmol) in THF (20 mL) at room temperature under N2 for 40 min., then one hour at 50° C., followed by purification of crude material using chromatography on silica gel (2:2:96 CH3OH—NH3 H2O—CH2Cl2), afforded the title compound (1.17 g, 74%) as white foam.

Quelle