Reaktion #728039

Reaktionsgleichung

Thiophene-2-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

4-(4-methyl-piperazin-1-yl)-phenylamine

→

title compound

Ausbeute 59.5%

Thiophene-2-carboxylic acid [4-(3-{[4-(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Ausbeute 59.5%

Lösungsmittel

THF

—

Hexanes

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA small screw cap test tube
2. 2
   TemperaturSubsequently, the reaction mixture was cooled to room temperature
3. 3
   SonstigeThe solid precipitate that formed

Vorschrift

A small screw cap test tube was charged with Thiophene-2-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (as prepared in Example 20, 100 mg, 0.257 mmol) and THF (2 mL). To the resulting solution was added 4-(4-methyl-piperazin-1-yl)-phenylamine (53.9 mg, 0.282 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. Hexanes were added to the reaction mixture. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 59% (86 mg, 0.153 mmol) of the title compound.

Quelle