Reaktion #728036

Reaktionsgleichung

Thiophene-2-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

THF

N-(4-aminophenyl)morpholine

→

title compound

Ausbeute 71.0%

Thiophene-2-carboxylic acid (4-{3-[(4-morpholin-4-yl-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carbonyl}-phenyl)-amide

Ausbeute 71.0%

Lösungsmittel

—

Hexanes

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA small screw cap test tube
2. 2
   TemperaturSubsequently, the reaction mixture was cooled to room temperature
3. 3
   SonstigeThe solid precipitate that formed

Vorschrift

A small screw cap test tube was charged with Thiophene-2-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (100 mg, 0.257 mmol) and THF (2 mL). To the resulting solution was added N-(4-aminophenyl)morpholine (50.2 mg, 0.282 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. EtOAc and Hexanes were added to the reaction mixture. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 71% (100 mg, 0.181 mmol) of the title compound.

Quelle