Reaktion #72717

Reaktionsgleichung

(2-chloro-benzoylamino)-acetic acid

(2-Chloro-benzoylamino)-acetic acid

sodium acetate

acetic anhydride

benzaldehyde

→

desired compound

Ausbeute 90.0%

4-Benzylidene-2-(2-chloro-phenyl)-4H-oxazol-5-one

Ausbeute 90.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere added dropwise at 30° C
2. 2
   Filtrationthe resulting solids were filtered
3. 3
   Waschenwashed with ethanol
4. 4
   Sonstigedried on vacuum

Vorschrift

To the stirred mixture of (2-chloro-benzoylamino)-acetic acid 21 (23.41 mmol), anhydrous sodium acetate (70.23 mmol), acetic anhydride (7 ml), and benzaldehyde (25.75 mmol) were added dropwise at 30° C. This mixture was then heated to 60° C. for 1 hr. The reaction mixture was poured into an ice-water solution and the resulting solids were filtered, washed with ethanol and dried on vacuum. The desired compound was obtained with a 90% yield.

Quelle