Reaktion #72716

Reaktionsgleichung

HCl

glycine

NaOH

o-chloro-benzoyl chloride

→

(2-Chloro-benzoylamino)-acetic acid

Ausbeute 80.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled again
2. 2
   ExtraktionExtraction of the aqueous solution
3. 3
   TrocknenThen, the combined organic layers were dried over MgSO4
4. 4
   Sonstigethe solvent was removed by reduced pressure
5. 5
   SonstigeThe residue was triturated
6. 6
   Filtrationthe product was collected by filtration in 80% yield

Vorschrift

To a stirred solution of glycine (100 mmol) and NaOH (100 mmol) in water (300 ml), at 5° C., o-chloro-benzoyl chloride (110 mmol) was added in small portions. The reaction mixture was stirred for 30 minutes at room temperature, then cooled again and acidified to pH=2 by addition of 6 M HCl. Extraction of the aqueous solution was performed with EtOAc. Then, the combined organic layers were dried over MgSO4 and the solvent was removed by reduced pressure. The residue was triturated in boiling chloroform, and the product was collected by filtration in 80% yield.

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