Reaktion #727124

Reaktionsgleichung

Methanol

[5-(4-ethylbenzyl)-2-hydroxybenzyl]phosphonic acid diethylester

bromotrimethylsilane

→

title compound

Ausbeute 85.8%

[5-(4-Ethylbenzyl)-2-hydroxybenzyl]phosphonic acid

Ausbeute 85.8%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred for 10 min at room temperature
2. 2
   SonstigeAfter evaporation
3. 3
   Sonstigethe residue was crystallized from ethyl acetate-n-hexane

Vorschrift

To a solution of [5-(4-ethylbenzyl)-2-hydroxybenzyl]phosphonic acid diethylester (0.40 g) in dichloromethane (7.8 mL) was added bromotrimethylsilane (0.8 mL) at 0° C., and the reaction mixture was stirred for 17 hr at room temperature. Methanol (1.1 mL) was added to the reaction mixture, and the mixture was stirred for 10 min at room temperature. After evaporation, the residue was crystallized from ethyl acetate-n-hexane to give the title compound (0.29 g) as a colorless crystal.

Quelle