Reaktion #727123

Reaktionsgleichung

[2-benzyloxy-5-(4-ethylbenzyl)benzyl]phosphonic acid diethylester

→

title compound

Ausbeute 97.0%

[5-(4-Ethylbenzyl)-2-hydroxybenzyl]phosphonic acid diethylester

Ausbeute 97.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtration and evaporation
2. 2
   Sonstigethe residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/3)

Vorschrift

To a solution of [2-benzyloxy-5-(4-ethylbenzyl)benzyl]phosphonic acid diethylester (1.03 g) in methanol (10.0 mL) was added 5% Pd—C (0.10 g), and the reaction mixture was stirred for 5 hr at room temperature under hydrogen gas atmosphere. After filtration and evaporation, the residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/3) to give the title compound (0.80 g) as a colorless oil.

Quelle