Reaktion #72710

Reaktionsgleichung

water

o-aminobenzoate

benzaldehyde

sodium hydrogen sulfite

dimethylacetamide

→

desired product

Ausbeute 85.0%

2-Phenyl-quinazolin-4-ol

Ausbeute 85.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   SonstigeA precipitate was formed
3. 3
   Sonstigecollected
4. 4
   Sonstigedried

Vorschrift

A mixture of o-aminobenzoate (7 mmol), benzaldehyde (7 mmol) and sodium hydrogen sulfite (10.5 mmol) in dimethylacetamide (10 ml) was heated with stirring at 150° C. overnight. Then, the reaction mixture was poured into water (300 ml). A precipitate was formed, collected and dried. Recristallization from benzene gave the desired product in 85% yield.

Quelle