Reaktion #726627

Reaktionsgleichung

1-ethynylcyclohexylamine

triethylamine

methylisocyanate

→

1-(1-ethynyl-cyclohexyl)-3-methylurea

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated down
2. 2
   Waschenwashed with aqueous potassium carbonate solution
3. 3
   SonstigeThe organic phase is dried
4. 4
   Sonstigeevaporated down

Vorschrift

A solution of 1 g (8 mmol) 1-ethynylcyclohexylamine and 2 mL (15 mmol) triethylamine in 10 mL acetonitrile is combined at ambient temperature with 0.5 g (9 mmol) methylisocyanate. The colourless suspension is stirred overnight at ambient temperature and then evaporated down. The residue is taken up in dichloromethane and washed with aqueous potassium carbonate solution. The organic phase is dried and evaporated down. Yield: 1.4 g (colourless solid)

Quelle