Reaktion #72633

Reaktionsgleichung

cyanoborohydride

2-amino-4,5-dimethylthiophene-3-carbonitrile

benzaldehyde

cyanoborohydride

→

2-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile

Lösungsmittel

acetic acid

dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed by filtration
2. 2
   Sonstigethe product was purified by prep HPLC

Vorschrift

To a solution of 2-amino-4,5-dimethylthiophene-3-carbonitrile (151 mg, 1.0 mmol) and benzaldehyde (106 mg, 1 mmol) in 15 mL of 4% acetic acid in dichloroethane was added silica supported cyanoborohydride (2.0 g. 2.0 mmol). The reaction was placed in a microwave reactor for 5 minutes at 135° C. Silica supported cyanoborohydride was removed by filtration, and the product was purified by prep HPLC using acetonitrile/water as solvent. MS 243 (MH+).

Quelle