Reaktion #726213

Reaktionsgleichung

8-bromo-2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

DMF

→

title compound

Ausbeute 83.0%

8-methyl-2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

Ausbeute 83.0%

Lösungsmittel

KF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was cooled down to room temperature
2. 2
   ExtraktionThe resulting solution was extracted several times with DCM
3. 3
   Einengenconcentrated
4. 4
   Sonstigepurified with column chromatography (silica, 10-40% Ethyl acetate in hexane)

Vorschrift

To a solution of 8-bromo-2,3-dihydro-1,4-benzodioxin-6-carbaldehyde (240 mg, 0.987 mmol) in DMF (5 mL) were added LiCL (126 mg, 2.96 mmol), Me Sn (0.137 mL, 0.987 mmol) and PdCL2(PPh)2 (35 mg, 0.049 mmol). After heated at 70° C. for 12 hr, the mixture was cooled down to room temperature and diluted with aqueous KF solution. The resulting solution was extracted several times with DCM. The organic parts were combined, concentrated and purified with column chromatography (silica, 10-40% Ethyl acetate in hexane) affording the title compound as an off-white solid (145 mg, 83%): MS (ES) m/z 179 (M+H)+.

Quelle