Reaktion #72621

ord-238b5ca57e524e038c88b39c4bc89991

Reaktionsgleichung

Cc1c(CO)sc(N)c1C#N
2-amino-5-(hydroxymethyl)-4-methylthiophene-3-carbonitrile
O=C(N=C=S)c1ccccc1
benzoyl isothiocyanate
→
Cc1c(CO)sc(NC(=S)NC(=O)c2ccccc2)c1C#N
N-(3-Cyano-5-(hydroxymethyl)-4-methylthiophen-2-ylcarbamothioyl)-benzamide

Edukte

Cc1c(CO)sc(N)c1C#N
2-amino-5-(hydroxymethyl)-4-methylthiophene-3-carbonitrile
O=C(N=C=S)c1ccccc1
benzoyl isothiocyanate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared as in example 1a from 2-amino-5-(hydroxymethyl)-4-methylthiophene-3-carbonitrile (Example 9b) and benzoyl isothiocyanate as a yellow solid. MS 332 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541421B2uspto-grants-2013_09