Reaktion #725934

Reaktionsgleichung

6-[4-(2-Benzyloxyacetylamino)phenoxy]hexanoic acid methyl ester

→

71

Ausbeute 65.3%

6-[4-(2-Hydroxyacetylamino)phenoxy]hexanoic acid methyl ester

Ausbeute 65.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeCatalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONwas distilled off
3. 3
   SonstigeCrude 71 was recrystallised in chloroform:hexane(1:6)

Vorschrift

6-[4-(2-Benzyloxyacetylamino)phenoxy]hexanoic acid methyl ester 70(1 g, 2.6 mmol) was dissolved in methanol (10 ml) in a pressure vessel, pd on carbon (5%, 250 mg) added and the mixture stirred under a hydrogen atm. (2 Kg) for 5 hrs. Catalyst was removed by filtration and methanol was distilled off. Crude 71 was recrystallised in chloroform:hexane(1:6) to get pure 71(0.5 g, 65.3%) as a white powder. M.p: 91.5-94° C.

Quelle