Reaktion #725894

Reaktionsgleichung

6-(4-Acetylaminophenoxy)hexanoic acid methyl ester

6-(4-Acetylamino-phenoxy)-hexanoic acid methyl ester

hydrochloric acid

→

20

Ausbeute 55.6%

6-(4-Amino-phenoxy)-hexanoic acid Hydrochloride

Ausbeute 55.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   Filtrationfiltered hot
4. 4
   Filtrationfiltered
5. 5
   Sonstigedried

Vorschrift

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

Quelle