Reaktion #725764

Reaktionsgleichung

4-chloro-3-methylthieno[2,3-d]pyrimidine

2-(2-chloro-6-methyl-4-propylphenoxy)ethylamine

triethylamine

→

desired Compound

Ausbeute 60.0%

4-[2-(2-chloro-6-methyl-4-propylphenoxy)ethylamino]-3-methylthieno[2,3-d]pyrimidine

Ausbeute 60.0%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe solution was heated
2. 2
   Temperaturunder reflux for 6 hours
3. 3
   workup.DISTILLATIONAt the end of this time, the solvent was distilled off
4. 4
   Waschenthe residue was washed with water
5. 5
   Sonstigedried in air
6. 6
   SonstigeIt was then recrystallised from a mixture of benzene and hexane

Vorschrift

3.7 g (0.02 mole) of 4-chloro-3-methylthieno[2,3-d]pyrimidine, 4.6 g (0.02 mole) of 2-(2-chloro-6-methyl-4-propylphenoxy)ethylamine and 2 g (0.02 mole) of triethylamine were dissolved in 50 ml of benzene, and the solution was heated under reflux for 6 hours. At the end of this time, the solvent was distilled off and the residue was washed with water and dried in air. It was then recrystallised from a mixture of benzene and hexane, to give 4.5 g (yield 60%) of the desired Compound No. 19 in the form of colourless needles melting at 66°-68° C.

Quelle