Reaktion #72571

Reaktionsgleichung

1-(2-bromo-ethyl)-4-nitro-benzene

2-amino-ethanol

→

title product

2-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture is evaporated to dryness
2. 2
   Sonstigethe residue obtained
3. 3
   Sonstigeis purified on silica gel (SiO2; gradient DCM/MeOH)

Vorschrift

A mixture of 1-(2-bromo-ethyl)-4-nitro-benzene (86.9 mmoles) and 2-amino-ethanol (869 mmoles) is heated at 150° C. under microwave activation for 10 minutes. The reaction mixture is evaporated to dryness and the residue obtained is purified on silica gel (SiO2; gradient DCM/MeOH) to yield the title product, which is used directly in the next Step.

Quelle