Reaktion #72560

Reaktionsgleichung

2-bromo-1-(4-chloro-phenyl)-ethanone

hydrazine-carbothioic acid O-ethyl ester

→

title product

5-(4-Chloro-phenyl)-3,6-dihydro-[1,3,4]thiadiazin-2-one

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solid formed
2. 2
   Filtrationis filtered off
3. 3
   Waschenwashed with acetonitrile and ethyl ether
4. 4
   Sonstigedried in vacuo

Vorschrift

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (90.71 mmoles) and hydrazine-carbothioic acid O-ethyl ester (90.71 mmoles) in acetonitrile (84 ml) is stirred at ambient temperature for 3 hours. The solid formed is filtered off, washed with acetonitrile and ethyl ether and then dried in vacuo to yield the title product, which is used directly in the next Step.

Quelle