Reaktion #725420

Reaktionsgleichung

phenylmagnesium bromide

1,3-dichloroacetone

acetic acid

Heptafluoropropyliodide

→

1,3-dichloro-2-(heptafluoropropyl)propan-2-ol

Lösungsmittel

ethyl ether

diethylether

diethylether

diethylether

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONWhen this addition
2. 2
   workup.ADDITIONTo this solution was added, at -78° C.
3. 3
   Sonstigethe temperature below -65° C
4. 4
   workup.STIRRINGThe mixture was then stirred four hours between -20° and -50° C
5. 5
   Temperaturto warm to 5° C.
6. 6
   Sonstigethe phases were separated
7. 7
   WaschenThe aqueous phase was washed with ether (2×25 ml)
8. 8
   Trocknendried (MgSO4)
9. 9
   Sonstigeevaporated

Vorschrift

Heptafluoropropyliodide (5 g, 6.9 mmole) was stirred at -78° C. in dry diethylether (20 ml). A solution of phenylmagnesium bromide in ethyl ether (10 ml of a 1.88 M solution) was added over a half-hour period. When this addition was complete, the reaction mixture was stirred at -20° C. for one hour. To this solution was added, at -78° C., 1,3-dichloroacetone (3.25 g, 25.6 mmole) in dry diethylether (20 ml) dropwise, keeping the temperature below -65° C. The mixture was then stirred four hours between -20° and -50° C. Glacial acetic acid (3 ml) in diethylether (5 ml) was added slowly followed by water (15 ml). The mixture was allowed to warm to 5° C. and then the phases were separated. The aqueous phase was washed with ether (2×25 ml). The ethereal extracts were combined, dried (MgSO4) and evaporated to give crude 1,3-dichloro-2-(heptafluoropropyl)propan-2-ol, which was used directly in the next step.

Quelle