Reaktion #72525

Reaktionsgleichung

(1R,5S)-3-aza-bicyclo[3.1.0]hexane

3,5-dimethyl-1H-pyrrole-2-carbaldehyde

formaldehyde

→

title product

4-[(1R,5S)-3-Aza-bicyclo[3.1.0]hex-3-ylmethyl]-3,5-dimethyl-1H-pyrrole-2-carbaldehyde

Lösungsmittel

acetic acid

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated to dryness
2. 2
   SonstigePurification by flash chromatography on silica gel (SiO2; heptane/AcOEt)

Vorschrift

To a solution of (1R,5S)-3-aza-bicyclo[3.1.0]hexane (10 mmoles) in acetic acid (10 ml) there are added 10 mmoles of 3,5-dimethyl-1H-pyrrole-2-carbaldehyde and formaldehyde (11 mmoles) 37% in water. The reaction mixture is stirred overnight at ambient temperature and then evaporated to dryness. Purification by flash chromatography on silica gel (SiO2; heptane/AcOEt) and then trituration in heptane to yield the title product.

Quelle