Reaktion #725136

Reaktionsgleichung

2-Hydroxy-3-methyl-1,6-naphthyridine

3-methyl-1,6-naphthyridin-2(1H)-one

N-(4-pyridinyl)methacrylamide

→

1,2,3,4-tetrahydro-3-methyl-2-oxo-1,6-naphthyridine

Reaktionsbedingungen

Vorschrift

2-Hydroxy-3-methyl-1,6-naphthyridine, the tautomeric form of 3-methyl-1,6-naphthyridin-2(1H)-one, was reportedly prepared by Ogata et al. [Chem. Pharm Bull. 20, 2264 (1972)] in two steps by first photocylization of N-(4-pyridinyl)methacrylamide to produce 1,2,3,4-tetrahydro-3-methyl-2-oxo-1,6-naphthyridine and then dehydrogenating said tetrahydro compound by heating it in acetic acid.

Quelle