Reaktion #72500

Reaktionsgleichung

Acetyl chloride

tert-butyl 2-(4-(methoxycarbonyl)benzoyl)hydrazine carboxylate

→

methyl 4-(hydrazinecarbonyl)benzoate

Ausbeute 96.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONadded as a solid)
2. 2
   SonstigeThe volatiles were removed in vacuo

Vorschrift

Acetyl chloride (11.8 g, 150 mmol) was added at 0° C. to methanol (200 mL) followed by the tert-butyl 2-(4-(methoxycarbonyl)benzoyl)hydrazine carboxylate (12.7 g, 43 mmol) (added as a solid). The reaction mixture was stirred at room temperature for 20 hours. The volatiles were removed in vacuo, affording methyl 4-(hydrazinecarbonyl)benzoate (8 g, 96%). The product was used without further purification. LCMS [M+H]: 195.

Quelle