Reaktion #72463

Reaktionsgleichung

4-bromo-2-nitroaniline

2-chloroacetyl chloride

→

N-(4-bromo-2-nitrophenyl)-2-chloroacetamide

Ausbeute 96.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter refluxing for 1.5 h
2. 2
   Sonstigethe solvent was removed under reduced pressure
3. 3
   SonstigeCrystallization from ethyl acetate/hexane

Vorschrift

To a solution of 4-bromo-2-nitroaniline (15.0 g, 69.1 mmol) was added drop wise 2-chloroacetyl chloride (9.4 g, 82.9 mmol) under nitrogen. After refluxing for 1.5 h, the reaction mixture was cooled to ambient temperature and the solvent was removed under reduced pressure. Crystallization from ethyl acetate/hexane afforded N-(4-bromo-2-nitrophenyl)-2-chloroacetamide (19.4 g, 66.1 mmol, 96%) as yellow needles.

Quelle