Reaktion #724494

Reaktionsgleichung

2-(2-chlorophenylcarbamoyl)-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride

compound 4

2-(2-chlorophenylcarbamoyl)-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride

→

compound 3

Ausbeute 98.2%

2-(2-chlorophenylcarbamoyl)-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole

Ausbeute 98.2%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe insolubes were removed by filtration
2. 2
   workup.ADDITIONTo the solution was added 5% sodium hydroxide solution
3. 3
   FiltrationThe precipitated crystals were filtered
4. 4
   Waschenwashed
5. 5
   Sonstigedried

Vorschrift

2-(2-chlorophenylcarbamoyl)-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride (compound 4) (8.2 g, 0.025M) was dissolved in water (250 ml) and the insolubes were removed by filtration. To the solution was added 5% sodium hydroxide solution with stirring until an alkaline pH (pH 9-11) was reached. The precipitated crystals were filtered, washed and dried to obtain compound 3 as white powdery crystals. (7.2 g, yield: 98.2%).

Quelle