Reaktion #724399

Reaktionsgleichung

methyl 2,5-dihydroxybenzoate

imidazole

t-butyldimethylsilyl chloride

→

methyl 2-hydroxy-5-(t-butyldimethylsilyloxy)benzoate

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextract with water
2. 2
   TrocknenDry the organic layer over MgSO4
3. 3
   Filtrationfilter
4. 4
   Sonstigeevaporate in vacuo

Vorschrift

Combine methyl 2,5-dihydroxybenzoate (8.45 g, 50.2 mmol), imidazole (4.1 g, 60.3 mmol), and t-butyldimethylsilyl chloride (9.09 g, 60.3 mmol) in dichloromethane (100 mL). After 30 minutes, dilute the reaction mixture with dichloromethane (100 mL) and extract with water. Dry the organic layer over MgSO4, filter and evaporate in vacuo to give methyl 2-hydroxy-5-(t-butyldimethylsilyloxy)benzoate.

Quelle