Reaktion #72428

Reaktionsgleichung

tert-butyl 3-((4-[3-(3-chlorophenyl)-4-(3,4-dimethylphenyl)but-1-yn-1-yl)benzyl)amino)propanoate

TFA

→

3-({4-[3-(3-chlorophenyl)-4-(3,4-dimethylphenyl)but-1-yn-1-yl]benzyl}amino)propanoic acid

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated under reduced pressure
2. 2
   workup.ADDITIONThe residue was diluted with CH2Cl2
3. 3
   workup.ADDITIONMeOH silica gel was added
4. 4
   Einengenconcentrated to dryness
5. 5
   Sonstigepurified by MPLC

Vorschrift

To a solution of tert-butyl 3-((4-[3-(3-chlorophenyl)-4-(3,4-dimethylphenyl)but-1-yn-1-yl)benzyl)amino)propanoate in CH2Cl2 (10 mL) was added TFA (1 mL) at room temperature and the mixture was stirred at room temperature for 16 h. The mixture was evaporated under reduced pressure. The residue was diluted with CH2Cl2:MeOH and the mixture was neutralized with NH3:MeOH silica gel was added, concentrated to dryness, then purified by MPLC using MeOH:CH2Cl2 and Compound 3 (129 mg).

Quelle